Transcriptional factor RUNX1: A potential therapeutic target for fibrotic pulmonary disease

Runt-related transcription factor-1 (RUNX1), also known as the core-binding factor alpha 2 subunit, is closely related to human leukemia. The functions of RUNX1 in modulating cell proliferation, differentiation, and survival multiple systems have been gradually discovered with emergence transgenic mice. a powerful implicated diverse signaling pathways cellular mechanisms that participate lung development pulmonary diseases. has recently identified target regulator fibrotic remodeling diseases, particularly kidney. However, role fibrosis unclear. Pulmonary characterized by obscure nosogenesis, limited therapy, poor prognosis. Moreover, population patients increasing. Thus, there an unmet need for therapeutic targets. In this review, we retrospectively discuss alteration mRNA expression RNA sequencing data lungs protein levels mouse fibrosis. Subsequently, focused on interaction between several involved Finally, review highlights potential slowing progression disease.